- PSYC5130 Biological Psychology
Cognitive neuroscience: brain dynamics in auditory and language processes. Brain imaging methods: multimodal imaging methods, optical brain imaging, and functional connectivity.
My research focuses on both the methodological development of multimodal brain imaging, and the application of these methods to study the spatiotemporal dynamics of the brain in various cognitive processes. Specifically, I examines the memory and attention processes involved in detecting changes in environmental stimulation (i.e., deviance or change detection), and the neural substrates underlying those processes. Stimulus deviance ranges from simple physical anomalies (e.g., tone change) to violation of abstract rules (e.g., syntactic violations) and, in conjunction with appropriate brain imaging techniques, can be used as a tool to investigate how the brain processes information across the continuum of complexity from simple stimulus perception to language comprehension. In order to investigate the interactions between different brain regions across time, I apply multimodal imaging methods, where I use an optical brain imaging method, the event-related optical signals (EROS), primarily, and combine it with electroencephalography (EEG), functional magnetic resonance imaging (fMRI), functional near-infra red spectroscopy (fNIRS), or transcranial magnetic stimulation (TMS) where suitable.
Tse, C.-Y., Rinne, T., Ng, K.-K., & Penney, T. B. (in press). The Functional Role of the Frontal Cortex in Pre-attentive Auditory Change Detection. Neuroimage.
Tse, C.-Y., Low, K. A., Fabiani, M., & Gratton, G. (2012). Rules rule! Brain Activity Dissociates the Representations of Stimulus Contingencies with Varying Levels of Complexity. Journal of Cognitive Neuroscience, 24(9), 1941–1959.
Lim, J., Ebstein, R., Tse, C.-Y., Monakhov, M., Lai, P. S., Dinges, D. F., & Kwok, K. (2012). Dopaminergic Polymorphisms Associated with Time-on-task Declines and Fatigue in the Psychomotor Vigilance Test. PLoS ONE, 7(3):e33767.doi:10.1371/journal.pone.0033767.
Tse, C.-Y., Gordon B. A., Fabiani, M., & Gratton, G. (2010). Frequency Analysis of the Visual Steady-state Response Measured with the Fast Optical Signal in Younger and Older adults. Biological Psychology, 85(1), 79-89.
Tse, C.-Y., & Penney, T. B. (2008). On the Functional Role of Temporal and Frontal Cortex Activation in Passive Detection of Auditory Deviance. Neuroimage, 41(4), 1462-1470.
Tse, C.-Y., Lee, C.-L., Sullivan, J., Garnsey, S. M., Dell, G. S., Fabiani, M., & Gratton, G. (2007). Imaging Cortical Dynamics of Language Processing with the Event-Related Optical Signal. Proceedings of the National Academy of Sciences, the United States, 104(43), 17157-17162.
Tse, C.-Y., & Penney, T. B. (2007). Preattentive Change Detection Using the Event-related Optical Signal. Engineering in Medicine and Biology Magazine, IEEE, 26(4), 52-58.
Tse, C.-Y., & Penney, T. B. (2006). Preattentive Timing of Empty Intervals is from Marker Offset to Onset. Psychophysiology, 43(2), 172-179.
Tse, C.-Y., Tien, K.-R., & Penney, T. B. (2006). Event-related Optical Imaging Reveals the Temporal Dynamics of Right Temporal and Frontal Cortex Activation in Pre-attentive Change Detection. Neuroimage, 29(1), 314-320.